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Proceedings Paper

Fast 3-D photoacoustic imaging in vivo with a high frequency ultrasound array toward clinical applications
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Paper Abstract

We present an in vivo reflection-mode photoacoustic microscopy system that performs B-scan imaging at 50 Hz with realtime beamforming and 3-D imaging of 166 B-scan frames at 1 Hz with post-beamforming. To our knowledge, this speed is currently the fastest in high frequency photoacoustic imaging. In addition, with a custom fiber based light delivery system, the imaging device is capable of performing handheld operation. Software for image processing and display with clinically user-friendly graphic user interface (GUI) is developed. The system has axial, lateral, and elevational resolutions of 25, 70, and 200 μm, respectively, and can image 3 mm deep in scattering biological tissue. Volumetric images of subcutaneous vasculature in murine are demonstrated in vivo. The system is anticipated to have potential clinical applications in skin melanoma detection due to its unique ability to image in realtime and to image anatomical sites inaccessible to other imaging systems.

Paper Details

Date Published: 24 February 2009
PDF: 9 pages
Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770G (24 February 2009); doi: 10.1117/12.809013
Show Author Affiliations
Liang Song, Washington Univ. in St. Louis (United States)
Konstantin Maslov, Washington Univ. in St. Louis (United States)
Rachel Bitton, Univ. of Southern California (United States)
K. Kirk Shung, Univ. of Southern California (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

Published in SPIE Proceedings Vol. 7177:
Photons Plus Ultrasound: Imaging and Sensing 2009
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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