Mechanical models are important in many areas of medicine and physiological research. These are usually based on continuum mechanics using macroscopic mechanical parameters. However, knowledge of the microscopic structure of tissue, that is, the organization of structural proteins, gives useful information for improving such models for a given tissue. In this paper we image the structural changes in these proteins under strain by using multiphoton microscopy. This gives insight into the response to the tissue at microscopic level and can be used to modify existing mechanical models of tissue. Specifically we imaged the straightening of collagen fibers in bovine chordae tendinae and related this to the macroscopic strain applied to the tissue.

Date Published: 13 February 2009
PDF: 6 pages
Proc. SPIE 7183, Multiphoton Microscopy in the Biomedical Sciences IX, 718325 (13 February 2009); doi: 10.1117/12.808984

Published in SPIE Proceedings Vol. 7183:
Multiphoton Microscopy in the Biomedical Sciences IX
Ammasi Periasamy; Peter T. C. So, Editor(s)