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Proceedings Paper

Frontal brain activation during a working memory task: a time-domain fNIRS study
Author(s): E. Molteni; G. Baselli; A. M. Bianchi; M. Caffini; D. Contini; L. Spinelli; A. Torricelli; S. Cerutti; R. Cubeddu
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Paper Abstract

We evaluated frontal brain activation during a working memory task with graded levels of difficulty in a group of 19 healthy subjects, by means of time-resolved fNIRS technique. Brain activation was computed, and was then separated into a "block-related" and a "tonic" components. Load-related increases of blood oxygenation were studied for the four different levels of task difficulty. Generalized Linear Models were applied to the data in order to explore the metabolic processes occurring during the mental effort and, possibly, their involvement in short term memorization. Results attest the presence of a persistent attentional-related metabolic activity, superimposed to a task-related mnemonic contribution. Moreover, a systemic component probably deriving from the extra-cerebral capillary bed was detected.

Paper Details

Date Published: 23 February 2009
PDF: 12 pages
Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 71613N (23 February 2009); doi: 10.1117/12.808972
Show Author Affiliations
E. Molteni, Politecnico di Milano (Italy)
G. Baselli, Politecnico di Milano (Italy)
A. M. Bianchi, Politecnico di Milano (Italy)
M. Caffini, INFM, CNR (Italy)
IFN, CNR (Italy)
Politecnico di Milano (Italy)
D. Contini, INFM, CNR (Italy)
IFN, CNR (Italy)
Politecnico di Milano (Italy)
L. Spinelli, INFM, CNR (Italy)
IFN, CNR (Italy)
Politecnico di Milano (Italy)
A. Torricelli, INFM, CNR (Italy)
IFN, CNR (Italy)
Politecnico di Milano (Italy)
S. Cerutti, Politecnico di Milano (Italy)
R. Cubeddu, INFM, CNR (Italy)
IFN, CNR (Italy)
Politecnico di Milano (Italy)

Published in SPIE Proceedings Vol. 7161:
Photonic Therapeutics and Diagnostics V
Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Kenton W. Gregory M.D.; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Guillermo J. Tearney; Justus F. R. Ilgner; Steen J. Madsen; Laura Marcu; Haishan Zeng, Editor(s)

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