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Proceedings Paper

Femtosecond laser scalpel technology for proteomic mass spectrometry
Author(s): C. L. Kalcic; T. C. Gunaratne; G. E. Reid; A. D. Jones; M. Dantus
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Paper Abstract

Tandem mass spectrometry is a widely used tool for molecular structure determination of biomolecules. Advances in proteome analysis depend on the development of improved methods for ion activation that yield greater sequence information, with selective control over the fragmentation chemistry. A novel activation method, femtosecond laser-induced ionization/dissociation, is described here, and compared to collision induced dissociation through the analysis of three peptides.

Paper Details

Date Published: 24 February 2009
PDF: 5 pages
Proc. SPIE 7203, Commercial and Biomedical Applications of Ultrafast Lasers IX, 72030C (24 February 2009); doi: 10.1117/12.808934
Show Author Affiliations
C. L. Kalcic, Michigan State Univ. (United States)
T. C. Gunaratne, Michigan State Univ. (United States)
G. E. Reid, Michigan State Univ. (United States)
A. D. Jones, Michigan State Univ. (United States)
M. Dantus, Michigan State Univ. (United States)

Published in SPIE Proceedings Vol. 7203:
Commercial and Biomedical Applications of Ultrafast Lasers IX
Joseph Neev; Stefan Nolte; Alexander Heisterkamp; Rick P. Trebino, Editor(s)

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