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Proceedings Paper

In vivo optical analysis of pancreatic cancer tissue in living model mice using fluorescence and Raman spectroscopic techniques
Author(s): Toshiaki Suzuki; Yusuke Hattori; Takashi Katagiri; Hiroki Mitsuoka; Ken-ichi Sato; Toru Asakura; Toru Shimosegawa; Hidetoshi Sato
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Paper Abstract

Living pancreatic cancer tissues grown subcutaneously in nude mice are studied by in vivo Raman spectroscopy and autofluorescence imaging. Comparing the same point spectra of alive pancreatic cancer tissue to that of the dead tissue, it is found that they are different each other. The results suggest that the spectral changes reflect the protein conformational changes in the tumor tissue with death of the host animal. From the result of autofluorescence study, in vivo autofluorescence imaging has potential as a method to assign the histological elements of the pancreatic cancer tissue without any staining. These results strongly suggest that combination of these techniques is very important to study biological tissue.

Paper Details

Date Published: 12 February 2009
PDF: 8 pages
Proc. SPIE 7182, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII, 718202 (12 February 2009); doi: 10.1117/12.808832
Show Author Affiliations
Toshiaki Suzuki, The Institute of Physical and Chemical Research-RIKEN (Japan)
Yusuke Hattori, The Institute of Physical and Chemical Research-RIKEN (Japan)
Takashi Katagiri, The Institute of Physical and Chemical Research-RIKEN (Japan)
Hiroki Mitsuoka, The Institute of Physical and Chemical Research-RIKEN (Japan)
Ken-ichi Sato, Tohoku Univ. (Japan)
Toru Asakura, Tohoku Univ. (Japan)
Miyagi Gakuin Women’s Univ. (Japan)
Toru Shimosegawa, Tohoku Univ. (Japan)
Hidetoshi Sato, The Institute of Physical and Chemical Research-RIKEN (Japan)


Published in SPIE Proceedings Vol. 7182:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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