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Proceedings Paper

Studying tumor metastasis by in vivo imaging and flow cytometer
Author(s): Xunbin Wei; Jin Guo; Guangda Liu; Yan Li; Yun Chen; Li Zhang; Yuan Tan; Tong Chen; Zhenqin Gu; Chen Wang
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Paper Abstract

Liver cancer is one of the most common malignancies in the world, with approximately 1,000,000 cases reported every year. This ranges from 15,000 cases in the United States to more than a 250,000 in China. About 80% of people with primary liver cancer are male. Although two-thirds of people have advanced liver disease when they seek medical help, one third of the patients have cancer that has not progressed beyond the liver. Primary liver cancer (hepatocellular carcinoma, or HCC) is associated with liver cirrhosis 60-80% of the time. HCC may metastasize to the lung, bones, kidney, and many other organs. Surgical resection, liver transplantation, chemotherapy and radiation therapy are the foundation of current HCC therapies. However the outcomes are poor-the survival rate is almost zero for metastatic HCC patients. Molecular mechanisms of HCC metastasis need to be understood better and new therapies must be developed to selectively target to unique characteristics of HCC cell growth and metastasis. We have developed the "in vivo microscopy" to study the mechanisms that govern liver tumor cell spread through the microenvironment in vivo in real-time confocal near-infrared fluorescence imaging. A recently developed "in vivo flow cytometer" and optical imaging are used to assess liver tumor cell spreading and the circulation kinetics of liver tumor cells. A real-time quantitative monitoring of circulating liver tumor cells by the in vivo flow cytometer will be useful to assess the effectiveness of the potential therapeutic interventions.

Paper Details

Date Published: 24 February 2009
PDF: 7 pages
Proc. SPIE 7178, Biophotonics and Immune Responses IV, 71780E (24 February 2009); doi: 10.1117/12.808610
Show Author Affiliations
Xunbin Wei, Fudan Univ. (China)
Jin Guo, Fudan Univ. (China)
Guangda Liu, Fudan Univ. (China)
Yan Li, Fudan Univ. (China)
Yun Chen, Fudan Univ. (China)
Li Zhang, Fudan Univ. (China)
Yuan Tan, Fudan Univ. (China)
Tong Chen, Huashan Hospital, Fudan Univ. (China)
Zhenqin Gu, Xinhua Hospital, Shanghai Jiao Tong Univ. (China)
Chen Wang, Univ. of Shanghai for Science and Technology (China)

Published in SPIE Proceedings Vol. 7178:
Biophotonics and Immune Responses IV
Wei R. Chen, Editor(s)

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