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Proceedings Paper

Modelling the optical response of human retinal photoreceptors to plane wave illumination with the finite integration technique
Author(s): Alireza Akhlagh Moayed; Shannon Dang; Omar M. Ramahi; Kostadinka K. Bizheva
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Paper Abstract

The early stages of ocular diseases such as Diabetic Retinopathy are manifested by morphological changes in retinal tissue occurring on cellular level. Therefore, a number of ophthalmic diseases can be diagnosed at an early stage by detecting spatial and temporal variations in the scattering profile of retinal tissue. It was recently demonstrated that, OCT can be used to probe the functional response of retinal photoreceptors to external light stimulation [1]-[3]. fUHROCT measures localized differential changes in the retina reflectivity over time resulting from external light stimulation of the retina. Currently the origins of the observed reflectivity changes are not well understood. However, due to the complex nature of retinal physiology using purely experimental approaches in this case is problematic. For example fUHROCT is sensitive to small changes in the refractive index of biological tissue which as demonstrated previously, can result from a number of processes such as membrane hyperpolarization, osmotic swelling, metabolic changes, etc. In this paper, we present a computational model of interaction between photoreceptor cells and optical plane wave based on the Finite Integration Technique (FIT).

Paper Details

Date Published: 24 February 2009
PDF: 6 pages
Proc. SPIE 7168, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII, 71680H (24 February 2009); doi: 10.1117/12.808544
Show Author Affiliations
Alireza Akhlagh Moayed, Univ. of Waterloo (Canada)
Shannon Dang, Univ. of Waterloo (Canada)
Omar M. Ramahi, Univ. of Waterloo (Canada)
Kostadinka K. Bizheva, Univ. of Waterloo (Canada)

Published in SPIE Proceedings Vol. 7168:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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