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Proceedings Paper

Treatment delivery platform for conformal catheter-based ultrasound hyperthermia
Author(s): Titania Juang; Jeffery Wootton; I-Chow Hsu; Chris Diederich
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Paper Abstract

A clinical treatment delivery platform has been developed for providing 3D controlled hyperthermia with catheter-based ultrasound applicators in conjunction with high dose rate (HDR) brachytherapy. This integrated system consists of hardware and software components required for thermal therapy delivery, treatment monitoring and control, and realtime and post-treatment analysis; and interstitial and endocavity ultrasound heating applicators. Hardware includes a 32-channel RF amplifier with independent power (0-25 W) and frequency (5-10 MHz) control for ultrasound power delivery and a 48-channel thermometry system compatible with 0.4 mm OD multi-sensor thermocouple probes. Software graphical user interfaces (GUI) are used to monitor and control both the amplifier and the thermometry system. The amplifier GUI controls, monitors, and records individual channel frequency and power values in real-time; the thermometry GUI monitors and records temperature and thermal dose values in real-time, as well as displaying and allowing dynamic control for temperature and thermal dose target thresholds. The thermometry GUI also incorporates registration of thermocouple positions relative to target anatomy and applicator transducers based on HDR planning tools (CT/MRI/US overlays) for improved treatment control and documentation. The interstitial (2.4 mm) and endocavity (6 mm) ultrasound hyperthermia applicators are composed of linear arrays of 1-4 tubular piezoceramic transducers - sectored at 90°, 180°, 270°, and 360° for single or dual directional heating patterns - that are compatible with plastic implant catheters. QA techniques specific to these catheter-based ultrasound applicators have been devised and implemented, and include rotational beam plots and dynamic force balance efficiency measurements, which are critical to establish applicator performance. A quality assurance test matrix has been devised and used to evaluate and characterize all components of this system prior to clinical implementation.

Paper Details

Date Published: 23 February 2009
PDF: 9 pages
Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 718109 (23 February 2009); doi: 10.1117/12.808339
Show Author Affiliations
Titania Juang, Univ. of California, San Francisco (United States)
Jeffery Wootton, Univ. of California, San Francisco (United States)
I-Chow Hsu, Univ. of California, San Francisco (United States)
Chris Diederich, Univ. of California, San Francisco (United States)

Published in SPIE Proceedings Vol. 7181:
Energy-based Treatment of Tissue and Assessment V
Thomas P. Ryan, Editor(s)

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