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Proceedings Paper

Relation between the neuronal and hemodynamic response in the lesioned rat spinal cord following peripheral nerve stimulation
Author(s): S. Dubeau; E. Beaumont; F. Lesage
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Paper Abstract

In this study, we explore the hemodynamic response in the lesioned rat spinal cord following peripheral nerve stimulation. Oxy and deoxy hemoglobin were measured (using a four color LED multispectral intrinsic optical imaging system) simultaneously with blood flow (laser speckle measurement). Both optical and electrophysiological data are compared spatially and against stimulation strength. When compared with non-lesioned animals, the hemodynamic response is seen to display significant differences exhibiting increased initial dip and decreased blood drain following stimulation. The origin of the difference is observed to be due to the vascular nature of the injury. The distinct hemodynamic responses may have a strong impact on General Linear Model based fMRI studies of spinal cord lesions due to the difficulty in separating vascular effects from neuronal plasticity following injury.

Paper Details

Date Published: 23 February 2009
PDF: 9 pages
Proc. SPIE 7180, Photons and Neurons, 718004 (23 February 2009); doi: 10.1117/12.808281
Show Author Affiliations
S. Dubeau, École Polytechnique de Montréal (Canada)
E. Beaumont, Hopital du Sacre-Coeur de Montréal (Canada)
Univ. de Montréal (Canada)
F. Lesage, École Polytechnique de Montréal (Canada)

Published in SPIE Proceedings Vol. 7180:
Photons and Neurons
Anita Mahadevan-Jansen; E. Duco Jansen, Editor(s)

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