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Proceedings Paper

Time-resolved fluorescence tomography in cancer research: backward versus toward geometry
Author(s): Laurent Guyon; Lionel Hervé; Jérome Boutet; Mathieu Debourdeau; Nadia Djaker; Anabela da Silva; Philippe Peltié; Jean-Marc Dinten; Philippe Rizo
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Paper Abstract

Fluorescence Diffuse Optical Tomography is an optical non-invasive molecular technique for cancer imaging. Depending on the accessibility of the organ two main geometries might be considered, reflection or transmission. We will present first experimental and reconstruction comparison between these two geometries, on a laboratory time resolved bench. Both acquisitions were made using a fluorophore inclusion positioned in a liquid phantom, with breast comparable optical properties. We successfully reconstructed all fluorophore positions examined in both geometries. Reflection geometry suffers of many drawbacks that we have to deal with. We will present all challenges it implies, and also what are the advantages to use time resolved techniques in both geometries.

Paper Details

Date Published: 12 February 2009
PDF: 11 pages
Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741X (12 February 2009); doi: 10.1117/12.808237
Show Author Affiliations
Laurent Guyon, Commissariat à l'Energie Atomique (France)
Lionel Hervé, Commissariat à l'Energie Atomique (France)
Jérome Boutet, Commissariat à l'Energie Atomique (France)
Mathieu Debourdeau, Commissariat à l'Energie Atomique (France)
Nadia Djaker, Commissariat à l'Energie Atomique (France)
Anabela da Silva, Commissariat à l'Energie Atomique (France)
Philippe Peltié, Commissariat à l'Energie Atomique (France)
Jean-Marc Dinten, Commissariat à l'Energie Atomique (France)
Philippe Rizo, Commissariat à l'Energie Atomique (France)

Published in SPIE Proceedings Vol. 7174:
Optical Tomography and Spectroscopy of Tissue VIII
Bruce J. Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva M. Sevick-Muraca; Robert R. Alfano, Editor(s)

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