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Proceedings Paper

Combined hyperspectral and spectral domain optical coherence tomography microscope for non-invasive hemodynamic imaging
Author(s): Melissa C. Skala; Hansford Hendargo; Andrew Fontanella; Mark W. Dewhirst; Joseph A. Izatt
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Paper Abstract

We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to non-invasively image changes in hemoglobin saturation, blood flow, microvessel morphology and sheer rate on the vessel wall with tumor growth. Changes in these hemodynamic variables were measured over 24 hours in dorsal skin fold window chamber tumors. There was a strong correlation between volumetric flow and hemoglobin saturation (ρ = 0.89, p = 9 × 10-6, N = 15), and a moderate correlation between shear rate on the vessel wall and hemoglobin saturation (ρ = 0.56, p = 0.03, N=15).

Paper Details

Date Published: 12 February 2009
PDF: 7 pages
Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71740I (12 February 2009); doi: 10.1117/12.808183
Show Author Affiliations
Melissa C. Skala, Duke Univ. (United States)
Hansford Hendargo, Duke Univ. (United States)
Andrew Fontanella, Duke Univ. (United States)
Mark W. Dewhirst, Duke Univ. (United States)
Joseph A. Izatt, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 7174:
Optical Tomography and Spectroscopy of Tissue VIII
Bruce J. Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva M. Sevick-Muraca; Robert R. Alfano, Editor(s)

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