
Proceedings Paper
Effects of micro- and macro-vascular perfusion during radiofrequency tumor ablationFormat | Member Price | Non-Member Price |
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Paper Abstract
Tumor ablation using radiofrequency (RF) energy is clinically used for treatment of various cancer types. During RF
ablation, an electrode is inserted into a tumor under imaging-guidance, and the tumor is heated by RF electric current
and cancer cells killed above temperatures of ~50 °C. One of the major factors affecting tissue temperature and ablation
zone dimensions is tissue perfusion. To examine perfusion effects, we created Finite Element Method computer models
of a clinically used RF ablation device, including temperature-dependent electrical and thermal tissue properties.
Microvascular perfusion was modeled according to Pennes' Bioheat Equation, and was varied with temperature to
include perfusion cessation due to coagulation at high temperatures. Microvascular perfusion rate was varied to represent
variations between patients by +/-1 standard deviation based on prior data measured in humans. Macro-vascular
perfusion was modeled by including a large vessel (10 mm diameter) in the model geometry, and assigning a convective
heat transfer coefficient as a boundary condition at the vessel wall. The vessel resulted in local deviation of the ablation
zone around the vessel, and resulted in a region of viable tissue near the vessel wall. Microvascular perfusion affected
overall size and geometry of the ablation zone. Ablation zone volume for average microvascular perfusion was 20.1 cm3,
and was 16.6 and 25.3 cm3 when perfusion rate was increased or reduced by 1 standard deviation. Both micro- and
macrovascular perfusion considerably affect tissue temperature and ablation zone. Patient-specific data on perfusion
would allow for more accurate estimates of ablation zone dimensions and improved treatment planning.
Paper Details
Date Published: 23 February 2009
PDF: 11 pages
Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810R (23 February 2009); doi: 10.1117/12.808047
Published in SPIE Proceedings Vol. 7181:
Energy-based Treatment of Tissue and Assessment V
Thomas P. Ryan, Editor(s)
PDF: 11 pages
Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810R (23 February 2009); doi: 10.1117/12.808047
Show Author Affiliations
D. Haemmerich, Medical Univ. of South Carolina (United States)
David J. Schutt, Medical Univ. of South Carolina (United States)
Published in SPIE Proceedings Vol. 7181:
Energy-based Treatment of Tissue and Assessment V
Thomas P. Ryan, Editor(s)
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