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Proceedings Paper

In vivo trans-rectal ultrasound coupled trans-rectal near-infrared optical tomography of canine prostate bearing transmissible venereal tumor
Author(s): Zhen Jiang; G. Reed Holyoak; Kenneth E. Bartels; Jerry W. Ritchey; Guan Xu; Charles F. Bunting; Gennady Slobodov; Jerzy S. Krasinski; Daqing Piao
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Paper Abstract

In vivo trans-rectal near-infrared (NIR) optical tomography is conducted on a tumor-bearing canine prostate with the assistance of trans-rectal ultrasound (TRUS). The canine prostate tumor model is made possible by a unique round cell neoplasm of dogs, transmissible venereal tumor (TVT) that can be transferred from dog to dog regardless of histocompatibility. A characterized TVT cell line was homogenized and passed twice in subcutaneous tissue of NOD/SCID mice. Following the second passage, the tumor was recovered, homogenized and then inoculated by ultrasound guidance into the prostate gland of a healthy dog. The dog was then imaged with a combined trans-rectal NIR and TRUS imager using an integrated trans-rectal NIR/US applicator. The image was taken by NIR and US modalities concurrently, both in sagittal view. The trans-rectal NIR imager is a continuous-wave system that illuminates 7 source channels sequentially by a fiber switch to deliver sufficient light power to the relatively more absorbing prostate tissue and samples 7 detection channels simultaneously by a gated intensified high-resolution CCD camera. This work tests the feasibility of detecting prostate tumor by trans-rectal NIR optical tomography and the benefit of augmenting TRUS with trans-rectal NIR imaging.

Paper Details

Date Published: 12 February 2009
PDF: 10 pages
Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741U (12 February 2009); doi: 10.1117/12.807990
Show Author Affiliations
Zhen Jiang, Oklahoma State Univ. (United States)
G. Reed Holyoak, Oklahoma State Univ. (United States)
Kenneth E. Bartels, Oklahoma State Univ. (United States)
Jerry W. Ritchey, Oklahoma State Univ. (United States)
Guan Xu, Oklahoma State Univ. (United States)
Charles F. Bunting, Oklahoma State Univ. (United States)
Gennady Slobodov, Univ. of Oklahoma Health Sciences Ctr. (United States)
Jerzy S. Krasinski, Oklahoma State Univ. (United States)
Daqing Piao, Oklahoma State Univ. (United States)

Published in SPIE Proceedings Vol. 7174:
Optical Tomography and Spectroscopy of Tissue VIII
Bruce J. Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva M. Sevick-Muraca; Robert R. Alfano, Editor(s)

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