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Proceedings Paper

Study of false positives in 5-ALA induced photodynamic diagnosis of bladder carcinoma
Author(s): Ronald O. P. Draga; Matthijs C. M. Grimbergen; Esther T. Kok; Trudy G. N. Jonges; J. L. H. Ruud Bosch
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Paper Abstract

Photodynamic diagnosis (PDD) is a technique that enhances the detection of tumors during cystoscopy using a photosensitizer which accumulates primarily in cancerous cells and will fluoresce when illuminated by violetblue light. A disadvantage of PDD is the relatively low specificity. In this retrospective study we aimed to identify predictors for false positive findings in PDD. Factors such as gender, age, recent transurethral resection of bladder tumors (TURBT), previous intravesical therapy (IVT) and urinary tract infections (UTIs) were examined for association with the false positive rates in a multivariate analysis. Data of 366 procedures and 200 patients were collected. Patients were instilled with 5-aminolevulinic acid (5-ALA) intravesically and 1253 biopsies were taken from tumors and suspicious lesions. Female gender and TURBT are independent predictors of false positives in PDD. However, previous intravesical therapy with Bacille Calmette-Guérin is also an important predictor of false positives. The false positive rate decreases during the first 9-12 weeks after the latest TURBT and the latest intravesical chemotherapy. Although shortly after IVT and TURBT false positives increase, PDD improves the diagnostic sensitivity and results in more adequate treatment strategies in a significant number of patients.

Paper Details

Date Published: 23 February 2009
PDF: 11 pages
Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 71611Q (23 February 2009);
Show Author Affiliations
Ronald O. P. Draga, Univ. Medisch Ctr. Utrecht (Netherlands)
Matthijs C. M. Grimbergen, Univ. Medisch Ctr. Utrecht (Netherlands)
Esther T. Kok, Univ. Medisch Ctr. Utrecht (Netherlands)
Trudy G. N. Jonges, Univ. Medisch Ctr. Utrecht (Netherlands)
J. L. H. Ruud Bosch, Univ. Medisch Ctr. Utrecht (Netherlands)

Published in SPIE Proceedings Vol. 7161:
Photonic Therapeutics and Diagnostics V
Henry Hirschberg M.D.; Brian Jet-Fei Wong M.D.; Kenton W. Gregory M.D.; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Guillermo J. Tearney; Justus F. R. Ilgner; Steen J. Madsen; Laura Marcu; Haishan Zeng, Editor(s)

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