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Proceedings Paper

Potential application of Chinese traditional medicine (CTM) as enhancer for tissue optical clearing
Author(s): Wei Chen; Jingying Jiang; Ruikang K. Wang; Kexin Xu
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Paper Abstract

Many biocompatible hyperosmotic agents such as dimethyl sulfoxide(DMSO) have been used as enhancers for tissue optical clearing technique. However, previous investigations showed that DMSO can induce bradycardia, respiratory problems, and alterations in blood pressure. Also, DMSO could potentially alter the chemical structure, and hence the functional properties, of cell membranes. In this talk, Borneol among natural and nontoxic CTMs was introduced as new enhancer for optical clearing of porcine skin tissue since it has been widely used as new penetration promoter in the field of trandermial drug delivery system(TDDS) and been proved to be effective. In the first, the spectral characteristics of borneol was obtained and analyzed by Fourier Transformation Infrared (FTIR) spectrophotometer. And further experimental studies were performed to probe if borneol is capable of optical clearing of porcine skin tissue in vitro with near infrared spectroscopy, double integrating-spheres system and Inverse Adding-Doubling(IAD) algorithm. Spectral results show that light penetration depth into skin tissue got the increase. Meanwhile, absorption coefficient and scattering coefficient of porcine skin treated by borneol got the decrease during the permeation of Borneol. Therefore, Borneol could be potentially used as enhancer for tissue optical clearing to improve non-invasive light-based diagnostic and imaging techniques while practically optical application and clinical safety are under consideration.

Paper Details

Date Published: 12 February 2009
PDF: 8 pages
Proc. SPIE 7176, Dynamics and Fluctuations in Biomedical Photonics VI, 71760K (12 February 2009); doi: 10.1117/12.807783
Show Author Affiliations
Wei Chen, Tianjin Univ. (China)
Jingying Jiang, Tianjin Univ. (China)
Ruikang K. Wang, Oregon Health & Science Univ. (United States)
Kexin Xu, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 7176:
Dynamics and Fluctuations in Biomedical Photonics VI
Valery Viktorovich Tuchin; Lihong V. Wang; Donald D. Duncan, Editor(s)

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