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Proceedings Paper

Time-domain fluorescence molecular tomography based on experimental data
Author(s): Limin Zhang; Jiao Li; Feng Gao; Huiyuan He; Huijuan Zhao
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Paper Abstract

We propose a 3D scheme for time-domain fluorescence molecular tomography within the normalized Born-ratio formulation. A finite element method solution to the Laplace transformed time-domain coupled diffusion equations is employed as the forward model, and the resultant linear inversions at two distinct transform-factors are solved with an algebraic reconstruction technique to separate fluorescent yield and lifetime images. By use of a multichannel time-correlation single photon counting system, we experimentally validate that the proposed scheme can achieve simultaneous reconstruction of the fluorescent yield and lifetime distributions with a reasonable accuracy.

Paper Details

Date Published: 12 February 2009
PDF: 8 pages
Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71741O (12 February 2009);
Show Author Affiliations
Limin Zhang, Tianjin Univ. (China)
Jiao Li, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Huiyuan He, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 7174:
Optical Tomography and Spectroscopy of Tissue VIII
Bruce J. Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva M. Sevick-Muraca; Robert R. Alfano, Editor(s)

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