
Proceedings Paper
Near-infrared spectroscopic studies of self-forming lipids and nanovesiclesFormat | Member Price | Non-Member Price |
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Paper Abstract
Lipids and liposomes have remained an active research topic for several decades due to their significance as membrane
model. Several vibrational spectroscopic techniques have been developed and employed to study the properties of lipids
and liposomes. In this study, near-infrared (NIR) spectroscopy has been used to analyze a suite of synthesized
PEGylated lipids trademarked as QuSomesTM. The three amphiphiles used in this study, differ in their apolar
hydrophobic chain length and contain various units of polar polyethylene glycol (PEG) head groups. In contrast to
conventional phospholipids, this new kind of lipids forms liposomes spontaneously upon hydration, without the supply
of external activation energy. Whilst the NIR spectra of QuSomesTM show a common pattern, differences in the spectra
are observed which enable the lipids to be distinguished. NIR absorption spectra of these new artificial lipids have been
recorded in the spectral range of 4800-9000 cm-1 (~2100-1100 nm) by using a new miniaturized spectrometer based on
micro-optical-electro-mechanical systems (MOEMS) technology. In particular, we have established specific band
structures as "molecular fingerprints" corresponding to overtones and combinations vibrational modes involving mainly
C-H and O-H functional groups for sample analysis of QuSomesTM. Moreover, we have demonstrated that the
nanovesicles formed by such lipids in polar solvents show high stability and obey Beer's law at low concentration. The
results reported in this study may find applications in various field including the development of lipids based drug
delivery systems.
Paper Details
Date Published: 16 February 2009
PDF: 8 pages
Proc. SPIE 7188, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI, 718809 (16 February 2009); doi: 10.1117/12.807406
Published in SPIE Proceedings Vol. 7188:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)
PDF: 8 pages
Proc. SPIE 7188, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI, 718809 (16 February 2009); doi: 10.1117/12.807406
Show Author Affiliations
Rajan K. Bista, Univ. of Nevada, Reno (United States)
Reinhard F. Bruch, Univ. of Nevada, Reno (United States)
Published in SPIE Proceedings Vol. 7188:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VI
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)
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