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Proceedings Paper

Empirical comparison of Pennes' bio-heat equation
Author(s): Luisiana X. Cundin; William P. Roach; Nancy Millenbaugh
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Paper Abstract

We solve a transient one-dimensional inhomogeneous Bio-Heat equation on a semi-infinite isotropic domain. The external source was modeled after Beer's law of deposition; the penetration depth was left arbitrary. The theoretical model is tested against experimental whole-body irradiation data. Pennes' thermal model correctly modeled the initial surface temperature rise, but experiment diverged from theoretical predictions after 30 minutes of exposure. Mortality statistics from a limited irreversibility study provided another means of comparison. All three major quartiles describing irreversibility are to be found well within the divergent space, where theory and experimental data diverge. Also, the mortality statistics seem to converge onto the divergence point.

Paper Details

Date Published: 24 February 2009
PDF: 9 pages
Proc. SPIE 7175, Optical Interactions with Tissue and Cells XX, 717516 (24 February 2009); doi: 10.1117/12.805577
Show Author Affiliations
Luisiana X. Cundin, Conceptual Mindworks, Inc. (United States)
William P. Roach, Air Force Research Lab. (United States)
Nancy Millenbaugh, General Dynamics (United States)

Published in SPIE Proceedings Vol. 7175:
Optical Interactions with Tissue and Cells XX
Steven L. Jacques; E. Duco Jansen; William P. Roach, Editor(s)

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