
Proceedings Paper
Skin optical clearing enhancement with penetration enhancer azone using spectroscopy and optical coherence tomographyFormat | Member Price | Non-Member Price |
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Paper Abstract
In order to find a non-invasive way to improve the efficacy of skin optical clearing with topically applied optical clearing
agents (OCA), we evaluated the effect of azone ® (epsilon-Laurocapram) as a chemical penetration enhancer on optical
clearing of intact skin in vitro. Fresh porcine skin with topical application of glycerol (G) mixed with water-soluble
azone (A) was investigated using near-infrared spectroscopy and optical coherence tomography (OCT). Light
transmittance at 1276 nm increased by 41% and diffuse reflectance at 1066 nm decreased by 29% at 60 min after
treatment with 40%G5%A on a spectrophotometer with an internal integrating sphere. 40% glycerol with addition of
azone was a more effective optical clearing agent than 40% and 80% glycerol. 60%G/5%A led to a 2-fold increase in
achievable OCT imaging depth and a 2.2-fold increase in light intensity reflected off the underneath needle surface after
60 minutes in the OCT in-depth reflectance profiles. In conclusion, skin optical clearing with the topical application of
glycerol was markedly enhanced by water-soluble azone. Skin permeation enhancing effect of azone accounts probably
for the skin clearing enhancement.
Paper Details
Date Published: 9 June 2008
PDF: 6 pages
Proc. SPIE 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 67910F (9 June 2008); doi: 10.1117/12.803974
Published in SPIE Proceedings Vol. 6791:
Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX
Valery V. Tuchin, Editor(s)
PDF: 6 pages
Proc. SPIE 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 67910F (9 June 2008); doi: 10.1117/12.803974
Show Author Affiliations
Xiangqun Xu, Zhejiang Sci-Tech Univ. (China)
Qiuhong Zhu, Zhejiang Sci-Tech Univ. (China)
Published in SPIE Proceedings Vol. 6791:
Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX
Valery V. Tuchin, Editor(s)
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