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Proceedings Paper

Optical phase contrast microscope imaging: a FDTD modeling approach
Author(s): Stoyan Tanev; James Pond; Paul Paddon; Valery V. Tuchin
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Paper Abstract

The Finite-Difference Time-Domain (FDTD) modeling technique is applied to build a simple simulation equivalent of an optical phase contrast microscope. The model is validated by demonstrating the effect of optical immersion on the optical phase contrast microscope image of a simple biological cell containing a cytoplasm, a nucleus and a membrane. To the best of our knowledge, this is the first study using the FDTD approach to construct optical phase contrast microscope images. The results demonstrate the potential of the FDTD modelling approach and extend its area of applicability a new biomedical research area.

Paper Details

Date Published: 9 June 2008
PDF: 11 pages
Proc. SPIE 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 67910E (9 June 2008); doi: 10.1117/12.803973
Show Author Affiliations
Stoyan Tanev, Carleton Univ. (Canada)
James Pond, Lumerical Solutions, Inc. (Canada)
Paul Paddon, Lumerical Solutions, Inc. (Canada)
Valery V. Tuchin, Saratov State Univ. (Russia)
Institute of Precise Mechanics and Control (Russia)

Published in SPIE Proceedings Vol. 6791:
Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX
Valery V. Tuchin, Editor(s)

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