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Proceedings Paper

Ultra-sensitive monitoring of analyte concentrations using phase sensitive spectral domain OCT
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Paper Abstract

The refractive index is a basic optical property of a medium which is of great importance in physics, chemistry and most of biomedical applications. In our current study we monitor the change in refractive index for aqueous solutions of glucose, CaCl2, MgCl2, NaCl, KCl and urea using a phase sensitive spectral domain optical coherence tomography (ph-SOCT) system. For instance, glucose induced changes in the phase are found to be 0.079 rad/mM in 200μm thick cuvette for clear media and that is in good agreement with literature and our previous obtained data using phase sensitive low coherence optical reflectometry(PS-OLCR). The importance of this study is to demonstrate the capability of ph-SOCT to monitor ultra small changes in refractive index in clear media and the accuracy for glucose sensing is estimated to be ±2.6×10-6.

Paper Details

Date Published: 9 June 2008
PDF: 7 pages
Proc. SPIE 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 67910A (9 June 2008); doi: 10.1117/12.803969
Show Author Affiliations
V. G. R. Manne, Univ. of Houston (United States)
R. K. Manapuram, Univ. of Houston (United States)
N. Sudheendran, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)
Saratov State Univ. (Russia)

Published in SPIE Proceedings Vol. 6791:
Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX
Valery V. Tuchin, Editor(s)

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