The calculation of permeability coefficient of analytes could potentially be used in a variety of basic science and clinical fields, as well as advanced diagnostic imaging. Before this can occur, a more thorough understanding of the diffusion rate of analytes in biological tissues is needed. For this task, we utilized Optical Coherence Tomography for the functional imaging of glucose diffusion through rabbit sclera tissues. The permeability coefficients were calculated for different concentrations of glucose solution as they diffused through the tissue. From the experiments performed it was noticed that the concentration of the analyte was inversely proportional to the permeability coefficient calculated. The permeability coefficient of glucose solution with lower concentration was faster when compared with higher concentration. The decrease in the permeability coefficient ranged from (1.67 ± 0.17) x 10^-5 cm/sec with the 10% glucose solution to (5.08 ± 0.23) x 10^-6cm/sec of 25% glucose solution. The results of this study could expand the use of the permeability coefficient into the field of diagnostic imaging.

Date Published: 9 June 2008
PDF: 5 pages
Proc. SPIE 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 679107 (9 June 2008); doi: 10.1117/12.803966

Published in SPIE Proceedings Vol. 6791:
Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX
Valery V. Tuchin, Editor(s)