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Proceedings Paper

Monte Carlo study of skin optical clearing to enhance light penetration in the tissue: implications for photodynamic therapy of acne vulgaris
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Paper Abstract

Result of Monte Carlo simulations of skin optical clearing is presented. The model calculations were carried out with the aim of studying of spectral response of skin under immersion liquids action and calculation of enhancement of light penetration depth. In summary, we have shown that: 1) application of glucose, propylene glycol and glycerol produced significant decrease of light scattering in different skin layers; 2) maximal clearing effect will be obtained in case of optical clearing of skin dermis, however, absorbed light fraction in skin dermis changed insignificantly, independently on clearing agent and place it administration; 3) in contrast to it, the light absorbed fraction in skin adipose layer increased significantly in case of optical clearing of skin dermis. It is very important because it can be used for development of optical methods of obesity treatment; 4) optical clearing of superficial skin layers can be used for decreasing of power of light radiation used for treatment of acne vulgaris.

Paper Details

Date Published: 5 June 2008
PDF: 12 pages
Proc. SPIE 7022, Advanced Laser Technologies 2007, 702209 (5 June 2008); doi: 10.1117/12.803909
Show Author Affiliations
Alexey N. Bashkatov, Saratov State Univ. (Russia)
Elina A. Genina, Saratov State Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)
Gregory B. Altshuler, Palomar Medical Technology, Inc. (United States)
Ilya V. Yaroslavsky, Palomar Medical Technology, Inc. (United States)

Published in SPIE Proceedings Vol. 7022:
Advanced Laser Technologies 2007
Ivan Alexandrov Shcherbakov; Risto Myllylä; Alexander V. Priezzhev; Matti Kinnunen; Vladimir I. Pustovoy; Mikhail Yu. Kirillin; Alexey P. Popov, Editor(s)

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