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Proceedings Paper

Antibody immobilization within glass microstructured fibers: a route to sensitive and selective biosensors
Author(s): T. M. Monro; Y. Ruan; H. Ebendorff-Heidepriem; H. Foo; P. Hoffmann; R. C. Moore
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Paper Abstract

Glass microstructured optical fibers have been rendered biologically active for the first time active via the immobilization of antibodies within the holes in the fiber cross-section. This has been done by introducing coating layers to the internal surfaces of soft glass fibers. The detection of proteins that bind to these antibodies has been demonstrated experimentally within this system via the use of fluorescence labeling. The approach combines the sensitivity resulting from the long interaction lengths of filled fibers with the selectivity provided by the use of antibodies.

Paper Details

Date Published: 16 May 2008
PDF: 4 pages
Proc. SPIE 7004, 19th International Conference on Optical Fibre Sensors, 70046Q (16 May 2008); doi: 10.1117/12.801887
Show Author Affiliations
T. M. Monro, Univ. of Adelaide (Australia)
Y. Ruan, Univ. of Adelaide (Australia)
H. Ebendorff-Heidepriem, Univ. of Adelaide (Australia)
H. Foo, Univ. of Adelaide (Australia)
P. Hoffmann, Univ. of Adelaide (Australia)
R. C. Moore, Univ. of Adelaide (Australia)

Published in SPIE Proceedings Vol. 7004:
19th International Conference on Optical Fibre Sensors
David Sampson; Stephen Collins; Kyunghwan Oh; Ryozo Yamauchi, Editor(s)

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