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Proceedings Paper

Large scale brain networks in epilepsy
Author(s): Hitten P. Zaveri; Steven M. Pincus; Irina I. Goncharova; Robert B. Duckrow; Susan S. Spencer M.D.
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Paper Abstract

Two studies of brain networks, performed on interictal intracranial EEGs recorded during the presurgical evaluation of patients with epilepsy, are presented in this report. In the first we examine pairwise relationships between pre-defined brain regions in 12 patients, 6 with medial temporal onset of seizures and 6 with frontal and parietal onset of seizures. We demonstrate that differences, in pairwise relationships between brain regions, allow a distinction of these two groups of patients. In the second study we evaluate short, mid, and long-distance brain connectivity as a function of distance to the seizure onset area in another 2 patients. We demonstrate that the measures of brain connectivity distinguish between brain areas which are close to and far from the seizure onset area. The results of the two studies may help both define large scale brain networks involved in the generation of seizures, and localize the area of seizure onset.

Paper Details

Date Published: 3 September 2008
PDF: 10 pages
Proc. SPIE 7074, Advanced Signal Processing Algorithms, Architectures, and Implementations XVIII, 70740T (3 September 2008); doi: 10.1117/12.801365
Show Author Affiliations
Hitten P. Zaveri, Yale Univ. (United States)
Steven M. Pincus, Consultant (United States)
Irina I. Goncharova, Yale Univ. (United States)
Robert B. Duckrow, Yale Univ. (United States)
Susan S. Spencer M.D., Yale Univ. (United States)

Published in SPIE Proceedings Vol. 7074:
Advanced Signal Processing Algorithms, Architectures, and Implementations XVIII
Franklin T. Luk, Editor(s)

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