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Proceedings Paper

DNA-programmed protein-nanoelectronic transducer array
Author(s): Gary Withey; Jin Ho Kim; Jimmy Xu
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Paper Abstract

By incorporating DNA as addressable linkers, we can direct and coordinate the simultaneous, parallel self-assembling and binding of multiple different redox proteins to designated nanoelectrodes. As a result, we have formed a nanoelectronic-protein transducer array which is capable of real-time, multiplexed detection of several analytes in parallel. The sequence-specificity of DNA hybridization provides the means of encoding spatial address instruction to the otherwise random self-assembling process and enables the desired programmability, scalability, and renewability. Results of this study, under an AFOSR MURI program, demonstrate the feasibility of a new paradigm of biosensing: detection of not only the presence of target substances but also the real-time activities of multiple biomolecules. In this system, the conjugated biomolecules and nanoelectronic components provide the active monitoring and mediating functions in real time, and can be integrated en masse into large arrays in a silicon-based integrated circuit.

Paper Details

Date Published: 29 August 2008
PDF: 12 pages
Proc. SPIE 7035, Biosensing, 70350L (29 August 2008); doi: 10.1117/12.797219
Show Author Affiliations
Gary Withey, Brown Univ. (United States)
Jin Ho Kim, Brown Univ. (United States)
Jimmy Xu, Brown Univ. (United States)

Published in SPIE Proceedings Vol. 7035:
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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