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Proceedings Paper

Micro-polarimetry for pre-clinical diagnostics of pathological changes in human tissues
Author(s): Andrzej Golnik; Natalia Golnik; Tadeusz Pałko; Tomasz Sołtysiński
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Paper Abstract

The paper presents a practical study of several methods of image analysis applied to polarimetric images of regular and malignant human tissues. The images of physiological and pathologically changed tissues from body and cervix of uterus, intestine, kidneys and breast were recorded in transmitted light of different polarization state. The set up of the conventional optical microscope with CCD camera and rotating polarizer's were used for analysis of the polarization state of the light transmitted through the tissue slice for each pixel of the camera image. The set of images corresponding to the different coefficients of the Stockes vectors, a 3×3 subset of the Mueller matrix as well as the maps of the magnitude and in-plane direction of the birefringent components in the sample were calculated. Then, the statistical analysis and the Fourier transform as well as the autocorrelation methods were used to analyze spatial distribution of birefringent elements in the tissue samples. For better recognition of tissue state we proposed a novel method that takes advantage of multiscale image data decomposition The results were used for selection of the optical characteristics with significantly different values for regular and malignant tissues.

Paper Details

Date Published: 22 April 2008
PDF: 9 pages
Proc. SPIE 7008, Eighth International Conference on Correlation Optics, 70081X (22 April 2008);
Show Author Affiliations
Andrzej Golnik, Warsaw Univ. (Poland)
Natalia Golnik, Warsaw Univ. of Technology (Poland)
Tadeusz Pałko, Warsaw Univ. of Technology (Poland)
Tomasz Sołtysiński, Warsaw Univ. of Technology (Poland)

Published in SPIE Proceedings Vol. 7008:
Eighth International Conference on Correlation Optics
Malgorzata Kujawinska; Oleg V. Angelsky, Editor(s)

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