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Proceedings Paper

Giant magnetoresistive biosensors for molecular diagnosis: surface chemistry and assay development
Author(s): Heng Yu; Sebastian J. Osterfeld; Liang Xu; Robert L. White; Nader Pourmand; Shan X. Wang
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Paper Abstract

Giant magnetoresistive (GMR) biochips using magnetic nanoparticle as labels were developed for molecular diagnosis. The sensor arrays consist of GMR sensing strips of 1.5 μm or 0.75 μm in width. GMR sensors are exquisitely sensitive yet very delicate, requiring ultrathin corrosion-resistive passivation and efficient surface chemistry for oligonucleotide probe immobilization. A mild and stable surface chemistry was first developed that is especially suitable for modifying delicate electronic device surfaces, and a practical application of our GMR biosensors was then demonstrated for detecting four most common human papillomavirus (HPV) subtypes in plasmids. We also showed that the DNA hybridization time could potentially be reduced from overnight to about ten minutes using microfluidics.

Paper Details

Date Published: 29 August 2008
PDF: 9 pages
Proc. SPIE 7035, Biosensing, 70350E (29 August 2008);
Show Author Affiliations
Heng Yu, Magarray, Inc. (United States)
Sebastian J. Osterfeld, Magarray, Inc. (United States)
Liang Xu, Stanford Univ. (United States)
Robert L. White, Magarray, Inc. (United States)
Nader Pourmand, Univ. of California, Santa Cruz (United States)
Shan X. Wang, Stanford Univ. (United States)

Published in SPIE Proceedings Vol. 7035:
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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