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Proceedings Paper

Plasmonic nanohole arrays for real-time multiplex biosensing
Author(s): Antoine Lesuffleur; Hyungsoon Im; Nathan C. Lindquist; Kwan Seop Lim; Sang-Hyun Oh
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Paper Abstract

Large-scale studies of biomolecular interactions required for proteome-level investigations can benefit from a new class of emerging surface plasmon resonance (SPR) sensors: nanohole arrays and surface plasmon (SP) enhanced optical transmission. In this paper we present a real-time, label-free multiplex SPR imaging sensor in a microarray format. The system presented is built around a low-cost microscope with laser illumination, integrated with microfluidics. The specific binding kinetics of biotin and streptavidin are measured from several sensing elements simultaneously, demonstrating the feasibility of using nanohole arrays as a high-throughput SPR microarray sensor.

Paper Details

Date Published: 29 August 2008
PDF: 10 pages
Proc. SPIE 7035, Biosensing, 703504 (29 August 2008); doi: 10.1117/12.794299
Show Author Affiliations
Antoine Lesuffleur, Univ. of Minnesota, Twin Cities (United States)
Hyungsoon Im, Univ. of Minnesota, Twin Cities (United States)
Nathan C. Lindquist, Univ. of Minnesota, Twin Cities (United States)
Kwan Seop Lim, Univ. of Minnesota, Twin Cities (United States)
Sang-Hyun Oh, Univ. of Minnesota, Twin Cities (United States)

Published in SPIE Proceedings Vol. 7035:
Manijeh Razeghi; Hooman Mohseni, Editor(s)

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