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Proceedings Paper

Positive changes in the myocardium of SHR rats induced by photon radiation
Author(s): I. M. Santalova; N. M. Zakharova; R. N. Khramov; I. V. Kraev; A. N. Murashev; A. S. Averin; L. Frachranurova
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Paper Abstract

Hypertensive SHR male rats were irradiated by a photon light-emitting diode matrix with a maximum irradiation at 612 nm with dose 1.44 J/cm2 per day . After a course of irradiation (13 days) the rhythmoinothropic characteristics of cardiac muscle significantly improved. Morphological analysis shown considerable changes in the structure of sarcoplasmic reticulum (SR), i.e. area of SR profiles increased more than twofold compared to control. This suggests a proportional increase in ability of SR to absorb calcium, due to both an increase in its buffer capacity and possibly, an improved functioning of Ca2+ ATPase of the reticulum. This could lead to an improvement in calcium homeostasis in the myocytes, and explain the improvement of the characteristics of cardiac muscle contraction-relaxation cycle. Furthermore, changes were observed in proportions of the myocardium capillaries (increased by 75%; compared to control, p<0.001) and in the area of mitochondrial profiles of the myocytes (increased by 13%, p<0.05). This lead to of more active metabolic processes and an energy rise occurring in myocardial cells after photon radiation treatment.

Paper Details

Date Published: 2 May 2008
PDF: 8 pages
Proc. SPIE 6991, Biophotonics: Photonic Solutions for Better Health Care, 699125 (2 May 2008); doi: 10.1117/12.781306
Show Author Affiliations
I. M. Santalova, Institute of Theoretical and Biophysics (Russia)
N. M. Zakharova, Institute of Cell Biophysics (Russia)
R. N. Khramov, Institute of Theoretical and Biophysics (Russia)
I. V. Kraev, Institute of Cell Biophysics (Russia)
A. N. Murashev, Institute of Bioorganic Chemistry (Russia)
A. S. Averin, Institute of Cell Biophysics (Russia)
L. Frachranurova, Institute of Theoretical and Biophysics (Russia)

Published in SPIE Proceedings Vol. 6991:
Biophotonics: Photonic Solutions for Better Health Care
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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