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Proceedings Paper

Sono-contrast spectroscopy for breast cancer detection
Author(s): Yan Yu; Lydia Liao M.D.
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Paper Abstract

In a preclinical study, we demonstrated that blood flow and tissue oxygenation could be manipulated by focused ultrasound; the effects of such manipulation were interrogated via optical spectroscopy at wavelengths where oxy- and deoxy-hemoglobin display different extinction properties. We have designed a clinical breast scanner based on these noninvasive techniques. In addition to the focused ultrasound field intersecting with the volume of optical illumination and points of spectral collection, a diagnostic quality breast imaging probe is incorporated into the scanhead to achieve image guidance. Experimental confirmation of the system performance of the focused ultrasound field properties, diagnostic imaging capabilities and NIR spectroscopy subsystem has been carried out to demonstrate readiness for a clinical study involving 200 patients who are scheduled to undergo ultrasound-guided biopsy to rule out breast cancers.

Paper Details

Date Published: 8 January 2008
PDF: 7 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68260F (8 January 2008); doi: 10.1117/12.779460
Show Author Affiliations
Yan Yu, Thomas Jefferson Univ. (United States)
Lydia Liao M.D., Cooper Univ. Hospital, Robert Wood Johnson Medical School (United States)

Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu M.D., Editor(s)

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