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Proceedings Paper

Photonic crystals utilized for label-free and amplified fluorescence biodetection
Author(s): Brian T. Cunningham
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Paper Abstract

Photonic crystals are fabricated on plastic surfaces, producing narrow bandwidth resonances at any desired wavelength. While shifts in the resonant wavelength quantify the density of adsorbed biomaterial, the resonances also enhance the output of adsorbed fluorophores. The combined attributes of photonic crystals enable highly sensitive label-free detection and greatly amplified sensitivity of any fluorescence-based assay for applications in life science research, drug discovery, and environmental pathogen detection. Applications for label-free selective detection of viral pathogens with sensitivity of ~30 focal forming units, and detection of spore pathogens with single-unit resolution are highlighted. Amplified fluorescence, meanwhile, enables gene expression detection of DNA at concentrations ~2 orders of magnitude lower than detection on optically passive surfaces.

Paper Details

Date Published: 30 April 2008
PDF: 12 pages
Proc. SPIE 6959, Micro (MEMS) and Nanotechnologies for Space, Defense, and Security II, 695910 (30 April 2008); doi: 10.1117/12.773626
Show Author Affiliations
Brian T. Cunningham, Univ. of Illinois at Urbana-Champaign (United States)

Published in SPIE Proceedings Vol. 6959:
Micro (MEMS) and Nanotechnologies for Space, Defense, and Security II
Thomas George; Zhongyang Cheng, Editor(s)

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