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Proceedings Paper

Intramyocardial capillary blood volume estimated by whole-body CT: validation by micro-CT
Author(s): Yue Dong M.D.; Patricia E. Beighley; Diane R Eaker; Mair Zamir; Erik L. Ritman M.D.
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Paper Abstract

Fast CT has shown that myocardial perfusion (F) is related to myocardial intramuscular blood volume (Bv) as Bv=A*F+B*F1/2 where A,B are constant coefficients. The goal of this study was to estimate the range of diameters of the vessels that are represented by the A*F term. Pigs were placed in an Electron Beam CT (EBCT) scanner for a perfusion CT scan sequence over 40 seconds after an IV contrast agent injection. Intramyocardial blood volume (Bv) and flow (F) were calculated in a region of the myocardium perfused by the LAD. Coefficients A and B were estimated over the range of F=1-5ml/g/min. After the CT scan, the LAD was injected with Microfil(R) contrast agent following which the myocardium was scanned by micro-CT at 20μm, 4μm and 2.5 μm cubic voxel resolutions. The Bv of the intramyocardial vessels was calculated for diameter ranges d=0-5, 5-10, 10-15, 15-20μm, etc. EBCT-derived data were presented so that it could be directly compared the micro-CT data. The results indicated that the blood in vessels less than 10μm in lumen diameter occupied 0.27-0.42 of total intravascular blood volume, which is in good agreement with EBCT-based values 0.28-0.48 (R2 =0.96). We conclude that whole-body CT image data obtained during the passage of a bolus of IV contrast agent can provide a measure of the intramyocardial intracapillary blood volume.

Paper Details

Date Published: 12 March 2008
PDF: 6 pages
Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 691624 (12 March 2008); doi: 10.1117/12.772713
Show Author Affiliations
Yue Dong M.D., Mayo Clinic College of Medicine (United States)
Patricia E. Beighley, Mayo Clinic College of Medicine (United States)
Diane R Eaker, Mayo Clinic College of Medicine (United States)
Mair Zamir, Univ. of Western Ontario (Canada)
Erik L. Ritman M.D., Mayo Clinic College of Medicine (United States)

Published in SPIE Proceedings Vol. 6916:
Medical Imaging 2008: Physiology, Function, and Structure from Medical Images
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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