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Proceedings Paper

Therapeutic targeting of tumors with imageable GFP-expressing Salmonella typhimurium auxotrophic mutants
Author(s): Robert M. Hoffman; Katsuhiro Hayashi; Ming Zhao
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Paper Abstract

Tumor targeting Salmonella typhimurium has been developed. These bacteria were mutagenized and a strain auxotrophic for leucine and arguine was selected. This strain was also engineered to express GFP. This train, termed A1, could target prostate tumors in nude mouse models and inhibit their growth. A1 was passaged through a tumor and re-isolated and termed A1-R. A1-R had greater antitumor efficacy and could cure breast, prostate, pancreatic, and lung tumors in nude mouse models.

Paper Details

Date Published: 13 February 2008
PDF: 7 pages
Proc. SPIE 6868, Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes, 68680K (13 February 2008); doi: 10.1117/12.772067
Show Author Affiliations
Robert M. Hoffman, AntiCancer, Inc. (United States)
Univ. of California, San Diego (United States)
Katsuhiro Hayashi, AntiCancer, Inc. (United States)
Ming Zhao, AntiCancer, Inc. (United States)

Published in SPIE Proceedings Vol. 6868:
Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes
Alexander P. Savitsky; Robert E. Campbell; Robert M. Hoffman, Editor(s)

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