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Proceedings Paper

Manipulating T-junction chip for the generation of uniform O/W and W/O emulsions
Author(s): Chia-Hsien Yeh; Sheng-Ji Lee; Meng Sun; Qun Fang; Yu-Cheng Lin
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Paper Abstract

The purpose of this study is to generate monodisperse oil-in-water (O/W) and water-in-oil (W/O) emulsions using microfluidic T-junction. The materials of poly methyl methacrylate (PMMA) (hydrophobic), polydimethylsiloxane (PDMS) (hydrophobic) and glass (hydrophilic) were employed for microfluidic chip fabrication. Our strategy is based on the shear focus effect and sheath effect (focusing) to form uniform self-assembling sphere structures, the so-called O/W and W/O emulsions, in the T-junction microchannel. Results show that the size from 31 μm to 43 μm in diameter of O/W emulsions was generated by using the glass-based microfluidic chip. In addition, results show that the size from 70 μm to 220 µm of W/O emulsions was available by utilizing the PMMA-based microfluidic chip. These W/O emulsions were further applied to Ca-alginate microparticles (Ca-alg MPs). And the results also show that the size from 410 μm to 700 μm of UV-Photopolymerized microparticles was available by utilizing the PDMS-based microfluidic chip. The proposed microfluidic chips are capable of generating relatively uniform micro-droplets and have the advantages of actively controlling the droplet diameter, and having a simple and low cost process, with a high throughput.

Paper Details

Date Published: 13 February 2008
PDF: 6 pages
Proc. SPIE 6886, Microfluidics, BioMEMS, and Medical Microsystems VI, 688610 (13 February 2008); doi: 10.1117/12.771516
Show Author Affiliations
Chia-Hsien Yeh, National Cheng Kung Univ. (Taiwan)
Sheng-Ji Lee, National Cheng Kung Univ. (Taiwan)
Meng Sun, Zhejiang Univ. (China)
Qun Fang, Zhejiang Univ. (China)
Yu-Cheng Lin, National Cheng Kung Univ. (Taiwan)

Published in SPIE Proceedings Vol. 6886:
Microfluidics, BioMEMS, and Medical Microsystems VI
Wanjun Wang; Claude Vauchier, Editor(s)

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