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Proceedings Paper

Partial volume effect of cingulum tract in diffusion-tensor MRI
Author(s): Ning Cao; Brian T. Gold; Jun Zhang
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Paper Abstract

Diffusion tensor imaging (DTI) represents a promising tool for the early diagnosis of certain brain diseases. Many DTI studies have compared differences in local diffusivity in specific region-of- interest (ROI) between patient and control groups to find possible disease markers. However, local diffusivity results may be influenced by partial volume effects (PVE), particularly in small white matter tracts that border grey matter tissue. Here, we investigated the influence of PVE on local diffusivity measurements in a small but critical white matter tract, the cingulum. Results demonstrated significant variability in PVE that contribute to local diffusivity in the cingulum. Our results highlight the need for careful consideration of PVE when computing diffusivity of small tissues.

Paper Details

Date Published: 12 March 2008
PDF: 9 pages
Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 69161U (12 March 2008);
Show Author Affiliations
Ning Cao, Univ. of Kentucky (United States)
Brian T. Gold, Univ. of Kentucky (United States)
Jun Zhang, Univ. of Kentucky (United States)

Published in SPIE Proceedings Vol. 6916:
Medical Imaging 2008: Physiology, Function, and Structure from Medical Images
Xiaoping P. Hu; Anne V. Clough, Editor(s)

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