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Proceedings Paper

Human airway measurement from CT images
Author(s): Jaesung Lee; Anthony P. Reeves; Sergei Fotin; Tatiyana Apanasovich; David Yankelevitz M.D.
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Paper Abstract

A wide range of pulmonary diseases, including common ones such as COPD, affect the airways. If the dimensions of airway can be measured with high confidence, the clinicians will be able to better diagnose diseases as well as monitor progression and response to treatment. In this paper, we introduce a method to assess the airway dimensions from CT scans, including the airway segments that are not oriented axially. First, the airway lumen is segmented and skeletonized, and subsequently each airway segment is identified. We then represent each airway segment using a segment-centric generalized cylinder model and assess airway lumen diameter (LD) and wall thickness (WT) for each segment by determining inner and outer wall boundaries. The method was evaluated on 14 healthy patients from a Weill Cornell database who had two scans within a 2 month interval. The corresponding airway segments were located in two scans and measured using the automated method. The total number of segments identified in both scans was 131. When 131 segments were considered altogether, the average absolute change over two scans was 0.31 mm for LD and 0.12 mm for WT, with 95% limits of agreement of [-0.85, 0.83] for LD and [-0.32, 0.26] for WT. The results were also analyzed on per-patient basis, and the average absolute change was 0.19 mm for LD and 0.05 mm for WT. 95% limits of agreement for per-patient changes were [-0.57, 0.47] for LD and [-0.16, 0.10] for WT.

Paper Details

Date Published: 27 March 2008
PDF: 8 pages
Proc. SPIE 6915, Medical Imaging 2008: Computer-Aided Diagnosis, 691518 (27 March 2008); doi: 10.1117/12.770601
Show Author Affiliations
Jaesung Lee, Cornell Univ. (United States)
Anthony P. Reeves, Cornell Univ. (United States)
Sergei Fotin, Cornell Univ. (United States)
Tatiyana Apanasovich, Cornell Univ. (United States)
David Yankelevitz M.D., Weill Cornell Medical College (United States)

Published in SPIE Proceedings Vol. 6915:
Medical Imaging 2008: Computer-Aided Diagnosis
Maryellen L. Giger; Nico Karssemeijer, Editor(s)

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