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Proceedings Paper

Contrast-enhanced dual-energy subtraction imaging using electronic spectrum-splitting and multi-prism x-ray lenses
Author(s): Erik Fredenberg; Björn Cederström; Mats Lundqvist; Carolina Ribbing; Magnus Åslund; Felix Diekmann; Robert Nishikawa; Mats Danielsson
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Paper Abstract

Dual-energy subtraction imaging (DES) is a method to improve the detectability of contrast agents over a lumpy background. Two images, acquired at x-ray energies above and below an absorption edge of the agent material, are logarithmically subtracted, resulting in suppression of the signal from the tissue background and a relative enhancement of the signal from the agent. Although promising, DES is still not widely used in clinical practice. One reason may be the need for two distinctly separated x-ray spectra that are still close to the absorption edge, realized through dual exposures which may introduce motion unsharpness. In this study, electronic spectrum-splitting with a silicon-strip detector is theoretically and experimentally investigated for a mammography model with iodinated contrast agent. Comparisons are made to absorption imaging and a near-ideal detector using a signal-to-noise ratio that includes both statistical and structural noise. Similar to previous studies, heavy absorption filtration was needed to narrow the spectra at the expense of a large reduction in x-ray flux. Therefore, potential improvements using a chromatic multi-prism x-ray lens (MPL) for filtering were evaluated theoretically. The MPL offers a narrow tunable spectrum, and we show that the image quality can be improved compared to conventional filtering methods.

Paper Details

Date Published: 18 March 2008
PDF: 12 pages
Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 691310 (18 March 2008); doi: 10.1117/12.770501
Show Author Affiliations
Erik Fredenberg, Royal Institute of Technology (Sweden)
Björn Cederström, Royal Institute of Technology (Sweden)
Mats Lundqvist, Sectra Mamea AB (Sweden)
Carolina Ribbing, Uppsala Univ. (Sweden)
Magnus Åslund, Sectra Mamea AB (Sweden)
Felix Diekmann, Charité - Univ. Hospital (Germany)
Robert Nishikawa, Univ. of Chicago (United States)
Mats Danielsson, Royal Institute of Technology (Sweden)

Published in SPIE Proceedings Vol. 6913:
Medical Imaging 2008: Physics of Medical Imaging
Jiang Hsieh; Ehsan Samei, Editor(s)

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