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Proceedings Paper

Design and evaluation of a new automated method for the segmentation and characterization of masses on ultrasound images
Author(s): Jing Cui; Berkman Sahiner; Heang-Ping Chan; Alexis Nees; Chintana Paramagul; Lubomir M. Hadjiiski; Chuan Zhou; Jiazheng Shi
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Paper Abstract

Segmentation of masses is the first step in most computer-aided diagnosis (CAD) systems for characterization of breast masses as malignant or benign. In this study, we designed an automated method for segmentation of masses on ultrasound (US) images. The method automatically estimated an initial contour based on a manually-identified point approximately at the mass center. A two-stage active contour (AC) method iteratively refined the initial contour and performed self-examination and correction on the segmentation result. To evaluate our method, we compared it with manual segmentation by an experienced radiologists (R1) on a data set of 226 US images containing biopsy-proven masses from 121 patients (44 malignant and 77 benign). Four performance measures were used to evaluate the segmentation accuracy; two measures were related to the overlap between the computer and radiologist segmentation, and two were related to the area difference between the two segmentation results. To compare the difference between the segmentation results by the computer and R1 to inter-observer variation, a second radiologist (R2) also manually segmented all masses. The two overlap measures between the segmentation results by the computer and R1 were 0.87+ 0.16 and 0.73+ 0.17 respectively, indicating a high agreement. However, the segmentation results between two radiologists were more consistent. To evaluate the effect of the segmentation method on classification accuracy, three feature spaces were formed by extracting texture, width-to-height, and posterior shadowing features using the computer segmentation, R1's manual segmentation, and R2's manual segmentation. A linear discriminant analysis classifier using stepwise feature selection was tested and trained by a leave-one-case-out method to characterize the masses as malignant or benign. For case-based classification, the area Az under the test receiver operating characteristic (ROC) curve was 0.90±0.03, 0.87±0.03 and 0.87±0.03 for the feature sets based on computer segmentation, R1's manual segmentation, and R2's manual segmentation, respectively.

Paper Details

Date Published: 17 March 2008
PDF: 9 pages
Proc. SPIE 6915, Medical Imaging 2008: Computer-Aided Diagnosis, 69150H (17 March 2008);
Show Author Affiliations
Jing Cui, Univ. of Michigan (United States)
Berkman Sahiner, Univ. of Michigan (United States)
Heang-Ping Chan, Univ. of Michigan (United States)
Alexis Nees, Univ. of Michigan (United States)
Chintana Paramagul, Univ. of Michigan (United States)
Lubomir M. Hadjiiski, Univ. of Michigan (United States)
Chuan Zhou, Univ. of Michigan (United States)
Jiazheng Shi, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 6915:
Medical Imaging 2008: Computer-Aided Diagnosis
Maryellen L. Giger; Nico Karssemeijer, Editor(s)

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