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Proceedings Paper

Ordered k-space acquisition in contrast enhanced magnetic resonance angiography (CE-MRA)
Author(s): B. Wu; J. R. Maclaren; R. P. Millane; R. Watts; P. J. Bones
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Paper Abstract

A new way of performing contrast enhanced magnetic resonance angiography (CE-MRA) is presented, in which the entire k-space is decomposed into interlaced subsets that are acquired sequentially. Based on a new parallel imaging technique, Generalized Unaliasing Incorporating object Support constraint and sensitivity Encoding (GUISE), reconstructions can be made using different subsets of k-space to reveal the level of contrast agent in the corresponding data acquisition time period. A proof-of-concept study using a custom made phantom was carried out to examine the utility of the new method. A quantity of contrast agent (copper sulfate solution) was injected into water flowing within a tube while data was acquired using an 8-coil receiver and the modified MRI sequence. A sequence of images was successfully reconstructed at high temporal resolution. This eliminated the need to precisely synchronize data acquisition with contrast arrival. Furthermore, subtraction of a pre-contrast data set prior to reconstruction, which eliminates the need for recovering the static background signal, has proven to be an effective way to improve the SNR and allow a higher temporal resolution to be achieved in recovering the dynamic signal containing contrast level change. Acceptably good reconstruction results were obtained at a temporal resolution equivalent to a 16-fold speed up compared to the time taken to fully sample k-space.

Paper Details

Date Published: 18 March 2008
PDF: 10 pages
Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 691346 (18 March 2008); doi: 10.1117/12.769429
Show Author Affiliations
B. Wu, Univ. of Canterbury (New Zealand)
J. R. Maclaren, Univ. of Canterbury (New Zealand)
R. P. Millane, Univ. of Canterbury (New Zealand)
R. Watts, Univ. of Canterbury (New Zealand)
P. J. Bones, Univ. of Canterbury (New Zealand)

Published in SPIE Proceedings Vol. 6913:
Medical Imaging 2008: Physics of Medical Imaging
Jiang Hsieh; Ehsan Samei, Editor(s)

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