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Proceedings Paper

Computerized image analysis for acetic acid induced intraepithelial lesions
Author(s): Wenjing Li; Daron G. Ferris M.D.; Rich W. Lieberman
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Paper Abstract

Cervical Intraepithelial Neoplasia (CIN) exhibits certain morphologic features that can be identified during a visual inspection exam. Immature and dysphasic cervical squamous epithelium turns white after application of acetic acid during the exam. The whitening process occurs visually over several minutes and subjectively discriminates between dysphasic and normal tissue. Digital imaging technologies allow us to assist the physician analyzing the acetic acid induced lesions (acetowhite region) in a fully automatic way. This paper reports a study designed to measure multiple parameters of the acetowhitening process from two images captured with a digital colposcope. One image is captured before the acetic acid application, and the other is captured after the acetic acid application. The spatial change of the acetowhitening is extracted using color and texture information in the post acetic acid image; the temporal change is extracted from the intensity and color changes between the post acetic acid and pre acetic acid images with an automatic alignment. The imaging and data analysis system has been evaluated with a total of 99 human subjects and demonstrate its potential to screening underserved women where access to skilled colposcopists is limited.

Paper Details

Date Published: 11 March 2008
PDF: 9 pages
Proc. SPIE 6914, Medical Imaging 2008: Image Processing, 69143A (11 March 2008);
Show Author Affiliations
Wenjing Li, STI Medical Systems (United States)
Daron G. Ferris M.D., Medical College of Georgia (United States)
Rich W. Lieberman, Univ. of Michigan Medical School (United States)

Published in SPIE Proceedings Vol. 6914:
Medical Imaging 2008: Image Processing
Joseph M. Reinhardt; Josien P. W. Pluim, Editor(s)

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