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Proceedings Paper

A fluorescence sectioning endoscopy using dynamic speckle illumination
Author(s): Jun Yin; Yonghong Shao; Junle Qu D.D.S.; Haoming Lin; Hanben Niu
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Paper Abstract

We present a novel fluorescence sectioning endoscopy that is based on a fiber-bundle and using speckle pattern illumination. The laser speckle pattern is produced by a rotating diffuser and delivered into the fiber bundle for whole-field excitation of the sample. The fluorescence is collected and transmitted to a CCD camera via the endoscope optics and fiber bundle. A sequence of fluorescent images are acquired and processed to reconstruct a 2D depth-resolved image of the sample. The fiber-bundle based endoscopy has similar sectioning capability to that of a laser scanning confocal microscopy but without scanning. Its other advantages include compactness and low cost, which makes it potentially viable for implementation in a portable clinical system.

Paper Details

Date Published: 21 February 2008
PDF: 6 pages
Proc. SPIE 6851, Endoscopic Microscopy III, 68510N (21 February 2008); doi: 10.1117/12.764304
Show Author Affiliations
Jun Yin, Huazhong Univ. of Science and Technology (China)
Shenzhen Univ. (China)
Yonghong Shao, Shenzhen Univ. (China)
Junle Qu D.D.S., Shenzhen Univ. (China)
Haoming Lin, Shenzhen Univ. (China)
Hanben Niu, Shenzhen Univ. (China)

Published in SPIE Proceedings Vol. 6851:
Endoscopic Microscopy III
Guillermo J. Tearney; Thomas D. Wang, Editor(s)

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