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Proceedings Paper

3D microscopy of gold nanoshells in tumors using two-photon-induced photoluminescence
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Paper Abstract

Gold nanoshells are a novel class of hybrid metal nanoparticles whose unique optical properties have spawned new applications including more sensitive molecular assays and cancer therapy. We report a new photo-physical property of nanoshells (NS) whereby these particles glow brightly when excited by near-infrared light. Specifically, we demonstrate NS excited at 780 nm produce strong two-photon induced photoluminescence (TPIP). We characterized the luminescence brightness of NS, comparing to that of fluorescein-labeled fluorescent beads (FB). We find that NS are 140 times brighter than FB. To demonstrate the potential application of this bright TPIP signal for biological imaging, we imaged the 3D distribution of gold nanoshells targeted to murine tumors.

Paper Details

Date Published: 21 February 2008
PDF: 8 pages
Proc. SPIE 6869, Plasmonics in Biology and Medicine V, 68690L (21 February 2008); doi: 10.1117/12.764123
Show Author Affiliations
Jaesook Park, The Univ. of Texas at Austin (United States)
Arnold Estrada, The Univ. of Texas at Austin (United States)
Jon A. Schwartz, Nanospectra Biosciences, Inc. (United States)
J. Donald Payne, Nanospectra Biosciences, Inc. (United States)
Andrew K. Dunn, The Univ. of Texas at Austin (United States)
James W. Tunnell, The Univ. of Texas at Austin (United States)

Published in SPIE Proceedings Vol. 6869:
Plasmonics in Biology and Medicine V
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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