
Proceedings Paper
Tumor necrosis factor-alpha induced enhancement of cryosurgeryFormat | Member Price | Non-Member Price |
---|---|---|
$17.00 | $21.00 |
Paper Abstract
Local recurrence of cancer after cryosurgery is related to the inability to monitor and predict destruction of cancer
(temperatures > -40°C) within an iceball. We previously reported that a cytokine adjuvant TNF-α could be used to
achieve complete cancer destruction at the periphery of an iceball (0 to -40°C). This study is a further development of
that work in which cryosurgery was performed using cryoprobes operating at temperatures > -40°C. LNCaP Pro 5 tumor
grown in a dorsal skin fold chamber (DSFC) was frozen at -6°C after TNF-α incubation for 4 or 24 hours. Tumors
grown in the hind limb were frozen with a probe tip temperature of -40°C, 4 or 24 hours after systemic injection with
TNF-α. Both cryosurgery alone or TNF-α treatment alone caused only a minimal damage to the tumor tissue at the
conditions used in the study. The combination of TNF-α and cryosurgery produced a significant damage to the tumor
tissue in both the DSFC and the hind limb model system. This augmentation in cryoinjury was found to be time-dependent
with 4-hour time period between the two treatments being more effective than 24-hour. These results suggests
the possibility of cryotreatment at temperatures > -40°C with the administration of TNF-α.
Paper Details
Date Published: 25 February 2008
PDF: 14 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68420R (25 February 2008); doi: 10.1117/12.764020
Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory M.D.; Reza S. Malek M.D.; Nikiforos Kollias; Brian Jet-Fei Wong M.D.; Henry Hirschberg M.D.; Justus F. R. Ilgner M.D.; Steen J. Madsen; Guillermo J. Tearney M.D.; Bernard Choi; Haishan Zeng, Editor(s)
PDF: 14 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68420R (25 February 2008); doi: 10.1117/12.764020
Show Author Affiliations
Raghav Goel, Univ. of Minnesota (United States)
Guilio F. Paciotti, CytImmune Sciences (United States)
Guilio F. Paciotti, CytImmune Sciences (United States)
John C. Bischof, Univ. of Minnesota (United States)
Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory M.D.; Reza S. Malek M.D.; Nikiforos Kollias; Brian Jet-Fei Wong M.D.; Henry Hirschberg M.D.; Justus F. R. Ilgner M.D.; Steen J. Madsen; Guillermo J. Tearney M.D.; Bernard Choi; Haishan Zeng, Editor(s)
© SPIE. Terms of Use
