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Proceedings Paper

Scatter sensitive microscopic techniques to identify contrasting mucosal structures in ultrahigh-resolution optical coherence tomograms of mouse colon
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Paper Abstract

Optical coherence tomography, optical coherence microscopy, reflectance confocal microscopy, and darkfield microscopy all derive contrast from the intensity of endogenous tissue scatter. We have imaged excised mouse colon tissue with these complimentary technologies to make conclusions about structural origins of scatter in the mouse colonic mucosa observed with endoscopic OCT. We find hyperintense scattering both from the cytoplasm of epithelial cells and from the boundary between epithelia and the lamina propria. We find almost no scatter from the portion of epithelial cells containing the nucleus. These observations substantiate explanations for the appearance of colonic crypts and the luminal surface.

Paper Details

Date Published: 21 February 2008
PDF: 12 pages
Proc. SPIE 6851, Endoscopic Microscopy III, 68510A (21 February 2008); doi: 10.1117/12.763968
Show Author Affiliations
Alexandre R. Tumlinson, The Univ. of Arizona (United States)
Cardiff Univ. (United Kingdom)
Lida P. Hariri, The Univ. of Arizona (United States)
Wolfgang Drexler, Cardiff Univ. (United Kingdom)
Jennifer K. Barton, The Univ. of Arizona (United States)

Published in SPIE Proceedings Vol. 6851:
Endoscopic Microscopy III
Guillermo J. Tearney; Thomas D. Wang, Editor(s)

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