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Proceedings Paper

Hybrid photodetector for single-molecule spectroscopy and microscopy
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Paper Abstract

We report benchmark tests of a new single-photon counting detector based on a GaAsP photocathode and an electron-bombarded avalanche photodiode developed by Hamamatsu Photonics. We compare its performance with those of standard Geiger-mode avalanche photodiodes. We show its advantages for FCS due to the absence of after-pulsing and for fluorescence lifetime measurements due to its excellent time resolution. Its large sensitive area also greatly simplifies setup alignment. Its spectral sensitivity being similar to that of recently introduced CMOS SPADs, this new detector could become a valuable tool for single-molecule fluorescence measurements, as well as for many other applications.

Paper Details

Date Published: 21 February 2008
PDF: 12 pages
Proc. SPIE 6862, Single Molecule Spectroscopy and Imaging, 68620F (21 February 2008); doi: 10.1117/12.763449
Show Author Affiliations
X. Michalet, Univ. of California, Los Angeles (United States)
Adrian Cheng, Univ. of California, Los Angeles (United States)
Joshua Antelman, Univ. of California, Los Angeles (United States)
Motohiro Suyama, Hamamatsu Photonics K.K. (Japan)
Katsushi Arisaka, Univ. of California, Los Angeles (United States)
Shimon Weiss, Univ. of California, Los Angeles (United States)

Published in SPIE Proceedings Vol. 6862:
Single Molecule Spectroscopy and Imaging
Jörg Enderlein; Zygmunt K. Gryczynski; Rainer Erdmann, Editor(s)

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