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Proceedings Paper

The evaluation of the photoaging of the human skin by three-dimensional polarization sensitive spectral domain optical coherence tomography
Author(s): Arata Miyazawa; Shingo Sakai; Masayuki Matsumoto; Noriaki Nakagawa; Masahiro Yamanari; Yoshiaki Yasuno
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Paper Abstract

Noninvasive evaluation of dermal degeneration is important for a diagnosis of photoaging. Polarization sensitive optical coherence tomography (PS-OCT) can measure the distribution of phase retardation caused by birefringence property of collagen. The PS-OCT has been reported as the technology of in vivo investigation of collagen structure in the skin. PS-spectral domain (SD)-OCT provides a three-dimensional phase retardation volume, and it provides an en face distribution map of the slopes of cumulative phase retardation. In this research, we measured the lateral orbital area and forehead of 7 young (age = 24.7±1.1) and 6 elder (age = 72.5±1.4) volunteers by a custom-built 840 nm fiber based PS-SD-OCT. This system can measure the skin birefringence three-dimensionally (5.5 sec for a 3-D volume). There was a significant difference in mean of the distribution of phase retardation slopes of the lateral orbital area between young and old cohorts (young: 0.356±0.0255 degree/μm; elder: 0.256±0.0118 degree/μm). However, there was no significant difference in forehead. On the other hand, the shapes of histogram was not normal distribution. Therefore, we calculated skewness and kurtosis of the distributions of slopes for the analysis. In the orbital area, there were also significant differences between young and old cohorts in skewness (y: 0.813±0.135; e: 1.51+/- 0.177) and kurtosis (y: 2.85±0.483; e: 5.23±0.862). In forehead, there was a significant difference between young and old cohorts in skewness (p=0.0289) in contrast with mean (p= 0.065).

Paper Details

Date Published: 8 February 2008
PDF: 4 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684207 (8 February 2008); doi: 10.1117/12.762674
Show Author Affiliations
Arata Miyazawa, Univ. of Tsukuba (Japan)
Shingo Sakai, Kanebo Cosmetics Inc. (Japan)
Masayuki Matsumoto, Kanebo Cosmetics Inc. (Japan)
Noriaki Nakagawa, Kanebo Cosmetics Inc. (Japan)
Masahiro Yamanari, Univ. of Tsukuba (Japan)
Yoshiaki Yasuno, Univ. of Tsukuba (Japan)

Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory M.D.; Reza S. Malek M.D.; Nikiforos Kollias; Brian Jet-Fei Wong M.D.; Henry Hirschberg M.D.; Justus F. R. Ilgner M.D.; Steen J. Madsen; Guillermo J. Tearney M.D.; Bernard Choi; Haishan Zeng, Editor(s)

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