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Proceedings Paper

A specially modified surface-enhanced Raman spectroscopy (SERS) substrate for biomedical applications
Author(s): Clement Yuen; Wei Zheng; Zhiwei Huang
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Paper Abstract

Hierarchically-ordered Au film-coated polystyrene beads have been well-known to be employed as surface enhanced Raman spectroscopy (SERS) substrate. In this study, we propose a novel and facile method to modify the performance of this SERS substrate and investigate the chemical components in saliva. Results have demonstrated that there is at least a 4-fold increase in SERS signals using the modified substrates compared to the non-modified substrates. Besides, the SERS performances of substrates modified by different preparation conditions are examined and compared. These findings show that our fabricated substrates are effective in further enhancing SERS signals and have potential for biomedical applications in trace analytes analysis.

Paper Details

Date Published: 21 February 2008
PDF: 4 pages
Proc. SPIE 6869, Plasmonics in Biology and Medicine V, 686905 (21 February 2008); doi: 10.1117/12.762434
Show Author Affiliations
Clement Yuen, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Zhiwei Huang, National Univ. of Singapore (Singapore)

Published in SPIE Proceedings Vol. 6869:
Plasmonics in Biology and Medicine V
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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