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Proceedings Paper

Availability of thiazone as an enhancer for optical clearing of skin tissue in vitro
Author(s): Jingying Jiang; Wei Chen; Ruikang K. Wang; Kexin Xu
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Paper Abstract

Dimethyl sulfoxside (DMSO) has been used as enhancer for tissue optical clearing technique. However, due to its potential toxicity and possible side effects, taking clearing effects and clinical availability into accounts, a new enhancer will be needed in order to facilitate practical application of tissue optical clearing technique to non-invasive light-based diagnostic and imaging technique. In this talk, it is our aim to introduce a new skin penetration promoter, thiazone, used in the fields of pharmaceutic industry, cosmetic, etc and investigate its availability as a new enhancer for tissue optical clearing technique. Firstly, we analyzed its structure, physical and chemical properties. And then we performed experimental investigation of the effect of DMSO and thiazone as enhancers mixed with polyethylene glycol (PEG) respectively on optical clearing of porcine skin tissue in vitro. Results of direct observation from camera reveal that thiazone has a higher penetration enhancing effect when compared with DMSO as an enhancer when porcine skin was topically impregnated by different mixed-solutions. Optical property parameters, obtained by using double integrating-spheres system and Inverse Adding-Doubling (IAD) method, showed that thiazone led to almost similar reduction in scattering to DMSO did during the same time period. Therefore, in terms of optical application and clinical safety, thiazone could be a better choice than DMSO as an enhancer for optical clearing of skin tissue.

Paper Details

Date Published: 15 February 2008
PDF: 8 pages
Proc. SPIE 6858, Optics in Tissue Engineering and Regenerative Medicine II, 68580N (15 February 2008); doi: 10.1117/12.762194
Show Author Affiliations
Jingying Jiang, Tianjin Univ. (China)
Wei Chen, Tianjin Univ. (China)
Ruikang K. Wang, Oregon Health & Science Univ. (United States)
Kexin Xu, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 6858:
Optics in Tissue Engineering and Regenerative Medicine II
Sean J. Kirkpatrick; Ruikang K. Wang, Editor(s)

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