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Proceedings Paper

Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography
Author(s): Wen-Chuan Kuo; Ming-Wei Hsiung; Jeou-Jong Shyu; Nai-Kuan Chou; Po-Nien Yang
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Paper Abstract

In this research, we have used an algorithm to extract four different optical parameters, including the scattering coefficient (μs), effective anisotropy factor (goff), birefringence coefficient (Δn), and fast-axis angle (β) from polarization-sensitive optical coherence tomography (PS-OCT) images. The proposed method was evaluated from a set of phantoms and it yielded valid results. We demonstrate that the optical characteristic of normal and different kinds of atherosclerotic lesions in human vessel can be quantitatively described. Whether change in these quantified optical properties could be used to discriminate between different types of human atherosclerotic plaques was examined.

Paper Details

Date Published: 8 February 2008
PDF: 9 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684223 (8 February 2008); doi: 10.1117/12.762170
Show Author Affiliations
Wen-Chuan Kuo, National Taiwan Normal Univ. (Taiwan)
Ming-Wei Hsiung, National Taiwan Normal Univ. (Taiwan)
Jeou-Jong Shyu, National Taiwan Univ. (Taiwan)
Nai-Kuan Chou, National Taiwan Univ. Hospital (Taiwan)
Po-Nien Yang, National Taiwan Normal Univ. (Taiwan)

Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory M.D.; Reza S. Malek M.D.; Nikiforos Kollias; Brian Jet-Fei Wong M.D.; Henry Hirschberg M.D.; Justus F. R. Ilgner M.D.; Steen J. Madsen; Guillermo J. Tearney M.D.; Bernard Choi; Haishan Zeng, Editor(s)

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